Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines
نویسندگان
چکیده
A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized using (2S)-1-azido-2-[bis(tertbutoxycarbonyl)-amino]-5-oxopentane as key-intermediate compound.
منابع مشابه
Expedient synthesis of chiral 1,2- and 1,4-diamines: protecting group dependent regioselectivity in direct organocatalytic asymmetric Mannich reactions.
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